California

Amphastar Pharmaceuticals Inc. is planning to expand its pharmaceutical manufacturing operations at its headquarters in Rancho Cucamonga. Project scope includes demolition of an estimated 140,000-sq-ft building; construction of a 279,507-sq-ft building with cleanrooms; and purchase and installation of automated high-speed vial and prefilled syringe production lines, stainless steel piping, fume hoods and wet laboratory, air handling, formulation, filtration, sterile filling, testing, bar coding, labeling, packaging, weighing and conveying equipment and systems. The expansion will quadruple plant capacity to produce injectables, inhalation and intranasal pharmaceutical products. EwingCole will provide architectural design services for the building. Construction is expected to begin in 2026. Amphastar Pharmaceuticals Inc., 11570 6th St., Rancho Cucamonga, CA 91730. IL#CA250706.

Kentucky

General Matter Inc. is planning to establish an estimated $1.5-billion uranium enrichment plant in Paducah, at the site of the former Paducah Gaseous Diffusion Plant. Project scope includes construction and/or renovation of building space and equipment foundations; and purchase and installation of columns, process vessels, storage tanks, and refining, extraction, separation and crystallization equipment. The facility will process at least 7,600 cylinders of uranium hexafluoride into low-enriched uranium for nuclear fuel. Construction is expected to begin in 2026. General Matter Inc., 1 Letterman Drive, Building D, 5th Floor, San Francisco, CA 94129. IL#KY250802.